Thus 5-BrU induces a point mutation via base substitution.
2.
Different base substitutions or amino acid substitutions can have different scores.
3.
It causes DNA damage through base substitution and increases the number of mutations.
4.
However, MutS? does not repair base substitutions.
5.
The MutS? pathway is involved primarily in base substitution and small-loop mismatch repair.
6.
The enzyme recognizes all base substitutions and insertions / deletions, and cleaves the 32 side of mismatched sites in both DNA strands with high specificity
7.
Silent mutations are base substitutions that result in no change of the amino acid or amino acid functionality when the altered messenger RNA ( mRNA ) is translated.
8.
Using an equation derived by Smith and Eyre-Walker, we can estimate the proportion of base substitutions fixed by natural selection, ?, using the following formula:
9.
"' Denaturing High Performance Liquid Chromatography "'( DHPLC ) is a method of chromatography for the detection of base substitutions, small deletions or insertions at the DNA.
10.
Note, however, the absolute rate of indels in most known genomes, including humans, tends to be markedly lower than base substitutions, except near highly repetitive regions, including microsatellites.
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